Demecarium Bromide CAS: 56-94-0 99 ٪

Appearance

White solid powder,

white powder

Identification

A: Infrared Absorption

Conform

B: Dissolve about 100 mg in 50 mL of 1 N sodium hydroxide, and reflux for 15 minutes. Cool, and add 3 mL of the refluxed solution to 25 mL of saturated sodium bicarbonate solution. Add, with mixing, 4 mL of N,N-dimethyl-pphenylenediamine dihydrochloride solution (1.5 in 10,000) and 2 mL of sodium hypochlorite solution (1.5 in 20,000): a violet-blue color is produced.

Conform

C: Dissolve about 50mg in 20ml of water, add

10mL of a 1 in 50 solution o ammonium reineckate in methanol, add allow to stand for

30 minutes with occasional swirling: a pink

Reineckate of demecarium forms, and it melts between 131° and 136°, with decomposition.

Conform

D: A solution of it responds to the tests for Bromide

Conform

PH

Between 5.0~7.0 [1 in 100]

5.8

Water

Not more than 2.0%

0.4%

Residue on ignition

No more than 0.1%

0.06%

Assay:

95.0-100.5% (calculated on the anhydrous).

100.1%

Related Substance(Limit of m-trimethylammoniophenol bromide)

No more intense than control preparation

Conform

conclusion

It conforms to USP40 standard